Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein
نویسندگان
چکیده
منابع مشابه
Processing of the amyloid precursor protein and its paralogues amyloid precursor-like proteins 1 and 2
Alzheimer’s disease (AD) is today the most common form of dementia. It is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. APP belongs to a conser...
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how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
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The proteolytic processing of the amyloidprotein precursor plays a key role in the development of Alzheimer’s disease. Cleavage of the amyloidprotein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving and -secretase, liberates amyloidprotein, a protein associated with the neurodegeneration seen in Alzheimer’s disease. Th...
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The possibility to understand the causes and treat the symptoms of Alzheimer's disease patients is still a great challenge. The triggering events leading to the selective neurodegeneration observed in Alzheimer's brains are not completely understood. This lack of understanding of the pathophysiological processes posses an important theoretical challenge for the rational design of pharmacologica...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m508340200